Neuroprotective effects of quercetin 3-O-sophoroside from Hibiscus rosa-sinensis Linn. on scopolamine-induced amnesia in mice

Journal of Functional Foods

Ruiqian Chen¹  Huimin Shen²  Xiaohua Huang³  Ganggang Shi⁴  Yilin Zheng⁵ 

[1] Department of Networks Center, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, Guangdong, China;Department of Neurology, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, Guangdong, China;Department of Pediatrics, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, Guangdong, China;Department of Pharmacology, Shantou University Medical College, Shantou 515041, Guangdong, China;Department of Pharmacy, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, Guangdong, China;

关键词: Alzheimer’s disease;    Hibiscus rosa-sinensis Linn.;    Quercetin 3-O-sophoroside;    Scopolamine;    Spatial cognition;    Cholinergic system function;   

DOI  :  

来源: DOAJ

【 摘 要 】

Quercetin 3-O-sophoroside (Q3OS) was isolated and identified from Hibiscus rosa-sinensis Linn. (HRS) for the first time. Although Q3OS is common glycosides, its therapeutic potential and mechanism of action against Alzheimer’s disease (AD) have rarely been reported.The results demonstrated that Q3OS treatment effectively ameliorated learning and memory impairment in mice with scopolamine (SCOP)-induced cognitive dysfunction by using the Morris water maze test. Nissl staining results revealed that Q3OS administration blocked neuronal loss in the hippocampal CA1 region. Immunohistochemistry and western blot results also indicated that Q3OS reversed the SCOP-induced decrease in ChAT expression, increase in AChE expression, and decrease in ACh.These findings suggested that Q3OS from HRS could be potentially used to prevent and treat AD, by exerting neuroprotective effects and these effects could be in response to its modification of the cholinergic system function. HRS can be potentially used as a neuroprotective nutrient in the prevention of AD.

【 授权许可】

Unknown