Breast Milk Lipidome Is Associated With Maternal Diet and Infants' Growth

Frontiers in Nutrition

David Hervas¹  Baoru Yang³  Kaisa M. Linderborg³  Linda Intonen³  Sonia González⁴  Joaquim Calvo-Lerma⁵  Marta Selma-Royo⁵  Maria Carmen Collado⁵  Cecilia Martínez-Costa⁶ 

[1]Department of Applied Statistics and Operations Research, and Quality, Universitat Politècnica de València, Valencia, Spain

[2]Department of Functional Biology, University of Oviedo, Oviedo, Spain

[3]Department of Life Technologies, Food Sciences, University of Turku, Turku, Finland

[4]Diet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain

[5]Institute of Agrochemistry and Food Technology (IATA-CSIC), Valencia, Spain

[6]Pediatric Gastroenterology and Nutrition Section, Hospital Clínico Universitario Valencia, INCLIVA Research Center, Valencia, Spain

关键词: breast milk composition;    fatty acids profile;    lactation;    diet;    dietary habits;    polyunsaturated fatty acids;   

DOI  :  10.3389/fnut.2022.854786

来源: DOAJ

【 摘 要 】

ObjectivesThe fatty acid (FA) composition of breast milk is a relevant aspect related to the development of the lactating infant. The present study aimed at exploring correlations between dietary intake of macro- and micronutrients with the FA profile in breast milk, and the possible implication for infants' growth.Study DesignBreast milk samples from a cohort of lactating women were collected 7–15 days postpartum. The FA profiles in triacylglycerol (TAG) and phospholipid (PL)-rich fractions were analyzed by gas chromatography. Diet was registered during the third trimester of pregnancy by means of a food frequency questionnaire (FFQ). In addition, anthropometric measurements of infants were collected from gestation and up to 12 months postpartum.ResultsThe FA profile in breast milk was characterized by a median of 37.4, 41.3 and 16.8% of saturated, monounsaturated, and polyunsaturated FAs, respectively. From the dietary components, zinc, iron, and B group vitamins were correlated positively with the proportion of total n-3 FAs in TAG and C20:5 n-3 in PL. Lycopene, vitamin E, zinc, and vitamin B2 showed a similar correlation with total polyunsaturated fatty acid (PUFA), total n-6 FAs, C20:4 n-6, and C18:2 n-6 in TAG. Regarding food groups, nuts showed the strongest association with several PUFA both in TAG and PL, while the vegetable group was also positively associated with C18:3 n-3. Furthermore, the concentration of linolenic acid (C18:3 n-3) and palmitic acid (C16:0) were positively associated with increased length for age (LFA) and weight for age (WFA) at 12 months compared with birth [ΔLFA −0.16 (−0.85, 0.37); ΔWFA −0.26 (−0.77, 0.21)].ConclusionsMothers' intake of nuts, dietary sources of zinc, iron, and B group vitamins were identified as potential predictors of a high-unsaturated FA profile in breast milk. In addition, linolenic and palmitic acids in breast milk were positively associated with infants' growth in the first year of life.

【 授权许可】

Unknown