期刊论文详细信息
Genes
Genetical Genomics of Tonic Immobility in the Chicken
Dominic Wright1  Per Jensen1  Jesper Fogelholm1  Robin Abbey-Lee1  Rie Henriksen1  Samuel Inkabi1  Andrey Höglund1  Martin Johnsson2 
[1] AVIAN Behavioural Genomics and Physiology Group, IFM Biology, Linköping University, 58183 Linköping, Sweden;The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Midlothian, Scotland EH25 9RG, UK;
关键词: QTL;    eQTL;    tonic immobility;    behaviour;    domestication;    muscle pH;   
DOI  :  10.3390/genes10050341
来源: DOAJ
【 摘 要 】

Identifying the molecular mechanisms of animal behaviour is an enduring goal for researchers. Gaining insight into these mechanisms enables us to gain a greater understanding of behaviour and their genetic control. In this paper, we perform Quantitative Trait Loci (QTL) mapping of tonic immobility behaviour in an advanced intercross line between wild and domestic chickens. Genes located within the QTL interval were further investigated using global expression QTL (eQTL) mapping from hypothalamus tissue, as well as causality analysis. This identified five candidate genes, with the genes PRDX4 and ACOT9 emerging as the best supported candidates. In addition, we also investigated the connection between tonic immobility, meat pH and struggling behaviour, as the two candidate genes PRDX4 and ACOT9 have previously been implicated in controlling muscle pH at slaughter. We did not find any phenotypic correlations between tonic immobility, struggling behaviour and muscle pH in a smaller additional cohort, despite these behaviours being repeatable within-test.

【 授权许可】

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