Genetics and Genomics of Social Behavior in a Chicken Model

Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation

article

Martin Johnsson¹  Rie Henriksen¹  Jesper Fogelholm¹  Andrey Höglund¹  Per Jensen¹  Dominic Wright¹ 

[1] AVIAN Behavioural Genomics and Physiology group, IFM Biology, Linköping University, 58183, Sweden;The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, EH25 9RG UK;Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, 750 07 Uppsala, Sweden

关键词: behavior;    eQTL;    QTL;    sociality;   

DOI  :  10.1534/genetics.118.300810

学科分类：医学（综合）

来源: Genetics Society of America

【 摘 要 】

The identification of genes affecting sociality can give insights into the maintenance and development of sociality and personality. In this study, we used the combination of an advanced intercross between wild and domestic chickens with a combined QTL and eQTL genetical genomics approach to identify genes for social reinstatement, a social and anxiety-related behavior. A total of 24 social reinstatement QTL were identified and overlaid with over 600 eQTL obtained from the same birds using hypothalamic tissue. Correlations between overlapping QTL and eQTL indicated five strong candidate genes, with the gene TTRAP being strongly significantly correlated with multiple aspects of social reinstatement behavior, as well as possessing a highly significant eQTL.

【 授权许可】

CC BY