Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk

Nutrients

Josep Vidal¹  Jesús Vioque²  Laura Compañ-Gabucio²  Aurora Bueno-Cavanillas²  Miguel Delgado-Rodríguez²  Vicente Martín-Sánchez²  Alejandro Oncina-Canovas²  Helmut Schröder³  Lucas Tojal-Sierra⁴  Olga Castañer⁴  Dora Romaguera⁴  Laura Torras⁴  Jose V. Sorli⁴  Juan C. Cenoz-Osinaga⁴  Dolores Corella⁴  Ángel M. Alonso-Gómez⁴  Xavier Pintó⁴  Julia Wärnberg⁴  José C. Fernández-Garcia⁴  José Lapetra⁴  Javier Barón-López⁴  Antonio Garcia-Rios⁴  Antoni Colom⁴  Marga Morey⁴  Emilio Ros⁴  Lluís Serra-Majem⁴  Itziar Abete⁴  Emili Corbella⁴  Clotilde Vázquez⁴  Araceli Muñoz-Garach⁴  Alfredo J. Martínez⁴  Miguel Ruiz-Canela⁴  Ramon Estruch⁴  Rosa Casas⁴  Miguel Á. Martínez-González⁴  Itziar Salaverria-Lete⁴  Maria del M. Bibiloni⁴  Josep A. Tur⁴  Javier Diez-Espino⁴  José M. Santos-Lozano⁴  Mireia Quifer⁴  Napoleón Pérez-Farinós⁴  Eva M. Asensio⁴  Almudena Sanchez-Villegas⁴  Pilar Matía-Martín⁵  Lidia Daimiel⁶  Nerea Becerra-Tomas⁷  Nancy Babio⁷  Mónica Bulló⁷  Christopher Papandreou⁷  Jordi Salas-Salvadó⁷  Andrés Díaz-López⁷ 

[1] CIBER Diabetes y enfermedades Metabólicos (CIBERDEM), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain;CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28009 Madrid, Spain;Cardiovascular Risk and Nutrition research group (CARIN), Hospital del Mar Research Institute (IMIM), 08003 Barcelona, Spain;Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), InstituteofHealth Carlos III, 28029 Madrid, Spain;Department of Endocrinology and Nutrition, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain;Nutritional Genomics and Epigenomics Group, IMDEA Food, CEI UAM + CSIC, 28049 Madrid, Spain;Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició, 43201 Reus, Spain;

关键词: sleep duration;    actigraphy;    serum uric acid;    serum uric acid to creatinine ratio;   

DOI  :  10.3390/nu11040761

来源: DOAJ

【 摘 要 】

The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndrome in the (Prevención con Dieta Mediterránea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations (β = −0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each 1-hour increment in sleep duration was inversely associated with SUA to creatinine ratio (β = −0.15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio.

【 授权许可】

Unknown