Local GABA concentration is related to network-level resting functional connectivity

eLife

Cassandra Sampaio-Baptista¹  Heidi Johansen-Berg²  Jacinta O’Shea³  Velicia Bachtiar⁴  Andrei S Ilie⁴  Nicola Filippini⁴  Christel A Gudberg⁴  Mark Woolrich⁴  Ugwechi Amadi⁴  Charlotte J Stagg⁴  Jamie Near⁴  Stephen M Smith⁴ 

[1] Department of Pharmacology, University of Oxford, Oxford, United Kingdom;Department of Psychiatry, University of Oxford, Oxford, United Kingdom;Department of Pharmacology, University of Oxford, Oxford, United Kingdom;Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom;

关键词: magnetic resonance spectroscopy;    GABA;    resting state fMRI;   

DOI  :  10.7554/eLife.01465

来源: DOAJ

【 摘 要 】

Anatomically plausible networks of functionally inter-connected regions have been reliably demonstrated at rest, although the neurochemical basis of these ‘resting state networks’ is not well understood. In this study, we combined magnetic resonance spectroscopy (MRS) and resting state fMRI and demonstrated an inverse relationship between levels of the inhibitory neurotransmitter GABA within the primary motor cortex (M1) and the strength of functional connectivity across the resting motor network. This relationship was both neurochemically and anatomically specific. We then went on to show that anodal transcranial direct current stimulation (tDCS), an intervention previously shown to decrease GABA levels within M1, increased resting motor network connectivity. We therefore suggest that network-level functional connectivity within the motor system is related to the degree of inhibition in M1, a major node within the motor network, a finding in line with converging evidence from both simulation and empirical studies.

【 授权许可】

Unknown