Perspectives on Vascular Regulation of Mechanisms Controlling Selective Immune Cell Function in the Tumor Immune Response

International Journal of Molecular Sciences

Michael Welsh¹ 

[1] Department of Medical Cell Biology, Uppsala University, Husargatan 3, Box 571, SE-75123 Uppsala, Sweden;

关键词: vasculature;    immune cells;    tumors;    cytokines;    cell adhesion molecules;    leakage;   

DOI  :  10.3390/ijms23042313

来源: DOAJ

【 摘 要 】

The vasculature plays a major role in regulating the tumor immune cell response although the underlying mechanisms explaining such effects remain poorly understood. This review discusses current knowledge on known vascular functions with a viewpoint on how they may yield distinct immune responses. The vasculature might directly influence selective immune cell infiltration into tumors by its cell surface expression of cell adhesion molecules, expression of cytokines, cell junction properties, focal adhesions, cytoskeleton and functional capacity. This will alter the tumor microenvironment and unleash a plethora of responses that will influence the tumor’s immune status. Despite our current knowledge of numerous mechanisms operating, the field is underexplored in that few functions providing a high degree of specificity have yet been provided in relation to the enormous divergence of responses apparent in human cancers. Further exploration of this field is much warranted.

【 授权许可】

Unknown