The role of noncoding RNAs in Parkinson’s disease: biomarkers and associations with pathogenic pathways

Journal of Biomedical Science

Ming-Che Kuo¹  Sam Chi-Hao Liu²  Ruey-Meei Wu²  Ya-Fang Hsu³ 

[1] Department of Medicine, Section of Neurology, Cancer Center, National Taiwan University Hospital;Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University;Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University;

关键词: Noncoding RNA;    Parkinson’s disease;    MicroRNA/miRNA;    PIWI-interacting RNA/piRNA;    Circular RNA/circRNA;    Long noncoding RNA/lncRNA;   

DOI  :  10.1186/s12929-021-00775-x

来源: DOAJ

【 摘 要 】

Abstract The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a growing area in cell biology. Increasing evidence has revealed canonical and noncanonical functions of long and small ncRNAs, including microRNAs, long ncRNAs (lncRNAs), circular RNAs, PIWI-interacting RNAs, and tRNA-derived fragments. These ncRNAs have the ability to regulate gene expression and modify metabolic pathways. Thus, they may have important roles as diagnostic biomarkers or therapeutic targets in various diseases, including neurodegenerative disorders, especially Parkinson’s disease. Recently, through diverse sequencing technologies and a wide variety of bioinformatic analytical tools, such as reverse transcriptase quantitative PCR, microarrays, next-generation sequencing and long-read sequencing, numerous ncRNAs have been shown to be associated with neurodegenerative disorders, including Parkinson’s disease. In this review article, we will first introduce the biogenesis of different ncRNAs, including microRNAs, PIWI-interacting RNAs, circular RNAs, long noncoding RNAs, and tRNA-derived fragments. The pros and cons of the detection platforms of ncRNAs and the reproducibility of bioinformatic analytical tools will be discussed in the second part. Finally, the recent discovery of numerous PD-associated ncRNAs and their association with the diagnosis and pathophysiology of PD are reviewed, and microRNAs and long ncRNAs that are transported by exosomes in biofluids are particularly emphasized.

【 授权许可】

Unknown