Evaluation of Arterial Spin Labeling MRI—Comparison with 15O-Water PET on an Integrated PET/MR Scanner

Diagnostics

Mathias Engström¹  Gunnar Antoni²  Eva Kumlien³  Mark Lubberink⁴  Torsten Danfors⁴  Elna-Marie Larsson⁴  Lieuwe Appel⁴  Markus Fahlström⁴  Johan Wikström⁴ 

[1] Applied Science Laboratory, GE Healthcare, 75185 Uppsala, Sweden;Department of Medicinal Chemistry, Uppsala University, 75185 Uppsala, Sweden;Department of Neuroscience, Uppsala University, 75185 Uppsala, Sweden;Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden;

关键词: ¹⁵O-water PET;    ASL;    CBF;    PET/MR;    validation;   

DOI  :  10.3390/diagnostics11050821

来源: DOAJ

【 摘 要 】

Cerebral blood flow (CBF) measurements are of high clinical value and can be acquired non-invasively with no radiation exposure using pseudo-continuous arterial spin labeling (ASL). The aim of this study was to evaluate accordance in resting state CBF between ASL (CBF_ASL) and ¹⁵O-water positron emission tomography (PET) (CBF_PET) acquired simultaneously on an integrated 3T PET/MR system. The data comprised ASL and dynamic ¹⁵O-water PET data with arterial blood sampling of eighteen subjects (eight patients with focal epilepsy and ten healthy controls, age 21 to 61 years). ¹⁵O-water PET parametric CBF images were generated using a basis function implementation of the single tissue compartment model. Cortical and subcortical regions were automatically segmented using Freesurfer. Average CBF_ASL and CBF_PET in grey matter were 60 ± 20 and 75 ± 22 mL/100 g/min respectively, with a relatively high correlation (r = 0.78, p < 0.001). Bland-Altman analysis revealed poor agreement (bias = −15 mL/100 g/min, lower and upper limits of agreements = −16 and 45 mL/100 g/min, respectively) with a negative relationship. Accounting for the negative relationship, the width of the limits of agreement could be narrowed from 61 mL/100 g/min to 35 mL/100 g/min using regression-based limits of agreements. Although a high correlation between CBF_ASL and CBF_PET was found, the agreement in absolute CBF values was not sufficient for ASL to be used interchangeably with ¹⁵O-water PET.

【 授权许可】

Unknown