Diagnostics | |
Evaluation of Arterial Spin Labeling MRI—Comparison with 15O-Water PET on an Integrated PET/MR Scanner | |
Mathias Engström1  Gunnar Antoni2  Eva Kumlien3  Mark Lubberink4  Torsten Danfors4  Elna-Marie Larsson4  Lieuwe Appel4  Markus Fahlström4  Johan Wikström4  | |
[1] Applied Science Laboratory, GE Healthcare, 75185 Uppsala, Sweden;Department of Medicinal Chemistry, Uppsala University, 75185 Uppsala, Sweden;Department of Neuroscience, Uppsala University, 75185 Uppsala, Sweden;Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden; | |
关键词: 15O-water PET; ASL; CBF; PET/MR; validation; | |
DOI : 10.3390/diagnostics11050821 | |
来源: DOAJ |
【 摘 要 】
Cerebral blood flow (CBF) measurements are of high clinical value and can be acquired non-invasively with no radiation exposure using pseudo-continuous arterial spin labeling (ASL). The aim of this study was to evaluate accordance in resting state CBF between ASL (CBFASL) and 15O-water positron emission tomography (PET) (CBFPET) acquired simultaneously on an integrated 3T PET/MR system. The data comprised ASL and dynamic 15O-water PET data with arterial blood sampling of eighteen subjects (eight patients with focal epilepsy and ten healthy controls, age 21 to 61 years). 15O-water PET parametric CBF images were generated using a basis function implementation of the single tissue compartment model. Cortical and subcortical regions were automatically segmented using Freesurfer. Average CBFASL and CBFPET in grey matter were 60 ± 20 and 75 ± 22 mL/100 g/min respectively, with a relatively high correlation (r = 0.78, p < 0.001). Bland-Altman analysis revealed poor agreement (bias = −15 mL/100 g/min, lower and upper limits of agreements = −16 and 45 mL/100 g/min, respectively) with a negative relationship. Accounting for the negative relationship, the width of the limits of agreement could be narrowed from 61 mL/100 g/min to 35 mL/100 g/min using regression-based limits of agreements. Although a high correlation between CBFASL and CBFPET was found, the agreement in absolute CBF values was not sufficient for ASL to be used interchangeably with 15O-water PET.
【 授权许可】
Unknown