A Mixed-Lipid Emulsion Containing Fish Oil for the Parenteral Nutrition of Preterm Infants: No Impact on Visual Neuronal Conduction

Nutrients

David Seki¹  David Berry¹  Margarita Thanhaeuser²  Andreas Repa²  Angelika Berger²  Hannah Schned²  Lukas Wisgrill²  Katharina Goeral²  Eva Schwindt²  Katrin Klebermass-Schrehof²  Christoph Binder²  Alexandra Thajer²  Vito Giordano²  Matteo Tardelli³  Nicholas Longford⁴ 

[1] Centre for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystem Science, Division of Microbial Ecology, University of Vienna, 1090 Vienna, Austria;Comprehensive Center for Pediatrics, Department of Pediatrics and Adolescent Medicine, Division of Neonatology, Intensive Care and Neuropediatrics, Medical University of Vienna, 1090 Vienna, Austria;Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY 10065, USA;Neonatal Data Analysis Unit, Department of Medicine, Chelsea and Westminster Campus, School of Public Health, Imperial College London, London SW10 9NH, UK;

关键词: fish oil;    omega-3 fatty acid;    lipid emulsion;    parenteral nutrition;    brain maturation;    visual evoked potential;   

DOI  :  10.3390/nu13124241

来源: DOAJ

【 摘 要 】

Fish oil is rich in omega-3 fatty acids and essential for neuronal myelination and maturation. The aim of this study was to investigate whether the use of a mixed-lipid emulsion composed of soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF-LE) compared to a pure soybean oil-based lipid emulsion (S-LE) for parenteral nutrition had an impact on neuronal conduction in preterm infants. This study is a retrospective matched cohort study comparing preterm infants <1000 g who received SMOF-LE in comparison to S-LE for parenteral nutrition. Visual evoked potentials (VEPs) were assessed longitudinally from birth until discharge. The latencies of the evoked peaks N2 and P2 were analyzed. The analysis included 76 infants (SMOF-LE: n = 41 and S-LE: n = 35) with 344 VEP measurements (SMOF-LE: n= 191 and S-LE n = 153). Values of N2 and P2 were not significantly different between the SMOF-LE and S-LE groups. A possible better treatment effect in the SMOF-LE group was seen as a trend toward a shorter latency, indicating faster neural conduction at around term-equivalent age. Prospective trials and follow-up studies are necessary in order to evaluate the potential positive effect of SMOF-LE on neuronal conduction and visual pathway maturation.

【 授权许可】

Unknown