Epidemiology and Genetic Analysis of SARS-CoV-2 in Myanmar during the Community Outbreaks in 2020

Viruses

Takashi Abe¹  Irina Chon²  Keita Wagatsuma²  Wint Wint Phyu²  Reiko Saito²  Hisami Watanabe³  Su Mon Kyaw Win³  Nay Chi Win³  Lasham Di Ja³  Hideki Hasegawa⁴  Shinji Watanabe⁴  Eh Htoo Pe⁵  Htay Htay Tin⁵  Kuroda Makoto⁶  Sekizuka Tsuyoshi⁶  Yadanar Kyaw⁷ 

[1] Division of Bioinformatics, Graduate School of Science and Technology, Niigata University, Niigata 950-2181, Japan;Division of International Health (Public Health), Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan;Infectious Diseases Research Center of Niigata University in Myanmar (IDRC), Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan;Influenza and Other Respiratory Virus Research Center, National Institute of Infectious Diseases, Tokyo 189-0002, Japan;National Health Laboratory, Department of Medical Services, Dagon Township, Yangon 111-91, Myanmar;Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo 189-0002, Japan;Respiratory Medicine Department, Thingangyun Sanpya General Hospital, Yangon 110-71, Myanmar;

关键词: SARS-CoV-2;    COVID-19;    community transmission;    case fatality rate;    reproductive number;    molecular epidemiology;   

DOI  :  10.3390/v14020259

来源: DOAJ

【 摘 要 】

We aimed to analyze the situation of the first two epidemic waves in Myanmar using the publicly available daily situation of COVID-19 and whole-genome sequencing data of SARS-CoV-2. From March 23 to December 31, 2020, there were 33,917 confirmed cases and 741 deaths in Myanmar (case fatality rate of 2.18%). The first wave in Myanmar from March to July was linked to overseas travel, and then a second wave started from Rakhine State, a western border state, leading to the second wave spreading countrywide in Myanmar from August to December 2020. The estimated effective reproductive number (R_t) nationwide reached 6–8 at the beginning of each wave and gradually decreased as the epidemic spread to the community. The whole-genome analysis of 10 Myanmar SARS-CoV-2 strains together with 31 previously registered strains showed that the first wave was caused by GISAID clade O or PANGOLIN lineage B.6 and the second wave was changed to clade GH or lineage B.1.36.16 with a close genetic relationship with other South Asian strains. Constant monitoring of epidemiological situations combined with SARS-CoV-2 genome analysis is important for adjusting public health measures to mitigate the community transmissions of COVID-19.

【 授权许可】

Unknown