Autophagy Modulation by Viral Infections Influences Tumor Development

Frontiers in Oncology

Marco Alifano¹  Lucas Leonardi³  Sophie Sibéril³  Isabelle Cremer³  Pierre-Emmanuel Joubert³ 

[1] Department of Thoracic Surgery, Hospital Cochin Assistance Publique Hopitaux de Paris, Paris, France;Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS1138, Centre de Recherche des Cordeliers, Paris, France;Sorbonne Université, Univ Paris, Paris, France;

关键词: tumor development and progression;    autophagy;    viral infection;    oncolytic virus;    oncogenic virus;    immunity;   

DOI  :  10.3389/fonc.2021.743780

来源: DOAJ

【 摘 要 】

Autophagy is a self-degradative process important for balancing cellular homeostasis at critical times in development and/or in response to nutrient stress. This is particularly relevant in tumor model in which autophagy has been demonstrated to have an important impact on tumor behavior. In one hand, autophagy limits tumor transformation of precancerous cells in early stage, and in the other hand, it favors the survival, proliferation, metastasis, and resistance to antitumor therapies in more advanced tumors. This catabolic machinery can be induced by an important variety of extra- and intracellular stimuli. For instance, viral infection has often been associated to autophagic modulation, and the role of autophagy in virus replication differs according to the virus studied. In the context of tumor development, virus-modulated autophagy can have an important impact on tumor cells’ fate. Extensive analyses have shed light on the molecular and/or functional complex mechanisms by which virus-modulated autophagy influences precancerous or tumor cell development. This review includes an overview of discoveries describing the repercussions of an autophagy perturbation during viral infections on tumor behavior.

【 授权许可】

Unknown