Histone deacetylase 6’s function in viral infection, innate immunity, and disease: latest advances

Frontiers in Immunology

Immunology

Huijun Zhang¹  Xiangwei Wang¹  Pengyuan Cheng¹  Yuefeng Sun¹  Min Qu¹  Xiangping Yin¹  Ashenafi Kiros Wubshet² 

[1] State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China;State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China;Department of Basic and Diagnostic Sciences, College of Veterinary Science, Mekelle University, Mekelle, Tigray, Ethiopia;

关键词: HDAC6;    viral infection;    innate immunity;    autophagy;    diseases;   

DOI  :  10.3389/fimmu.2023.1216548

 received in 2023-05-04, accepted in 2023-07-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

In the family of histone-deacetylases, histone deacetylase 6 (HDAC6) stands out. The cytoplasmic class IIb histone deacetylase (HDAC) family is essential for many cellular functions. It plays a crucial and debatable regulatory role in innate antiviral immunity. This review summarises the current state of our understanding of HDAC6’s structure and function in light of the three mechanisms by which it controls DNA and RNA virus infection: cytoskeleton regulation, host innate immune response, and autophagy degradation of host or viral proteins. In addition, we summed up how HDAC6 inhibitors are used to treat a wide range of diseases, and how its upstream signaling plays a role in the antiviral mechanism. Together, the findings of this review highlight HDAC6’s importance as a new therapeutic target in antiviral immunity, innate immune response, and some diseases, all of which offer promising new avenues for the development of drugs targeting the immune response.

【 授权许可】

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Copyright © 2023 Qu, Zhang, Cheng, Wubshet, Yin, Wang and Sun