Phytotherapeutics oridonin and ponicidin show additive effects combined with irradiation in pancreatic cancer in vitro

Radiology and Oncology

Liermann Jakob¹  Weber Klaus-Josef¹  Naumann Patrick¹  Schmid Thomas E.²  Combs Stephanie E.²  Debus Jürgen²  Fortunato Franco³ 

[1] Department of Radiation Oncology, Heidelberg University Hospital, INF 400, 69120, Heidelberg, Germany;Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany;Heidelberg University Hospital, Section Surgical Research, Heidelberg, Germany;

关键词: oridonin;    ponicidin;    irradiation;    pancreatic cancer;    γh2ax;    radiosensitivity;   

DOI  :  10.1515/raon-2017-0048

来源: DOAJ

【 摘 要 】

Chemoradiation of locally advanced non-metastatic pancreatic cancer can lead to secondary operability by tumor mass reduction. Here, we analyzed radiomodulating effects of oridonin and ponicidin in pancreatic cancer in vitro. Both agents are ent-kaurane diterpenoids, extracted from Isodon rubescens, a plant that is well known in Traditional Chinese Medicine. Cytotoxic effects have recently been shown in different tumor entities for both agents.

【 授权许可】

Unknown