Phytotherapeutics oridonin and ponicidin show additive effects combined with irradiation in pancreatic cancer in vitro

Radiology and Oncology

Dr. Jakob Liermann¹  Patrick Naumann²  Klaus-Josef Weber²  Stephanie E. Combs³  Thomas E. Schmid⁴  Jürgen Debus⁴  Franco Fortunato⁵ 

[1]Corresponding authorDepartment of Radiation Oncology, Heidelberg University Hospital, INF 400, 69120, Heidelberg, Germany

[2]Department of Radiation Oncology, Heidelberg University Hospital, INF 400, 69120, Heidelberg, GermanyOther articles by this author:

[3]Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Munich, GermanyInstitute of Innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Helmholtz Zentrum München, Neuherberg, GermanyOther articles by this author:

[4]Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Munich, GermanyOther articles by this author:

[5]Heidelberg University Hospital, Section Surgical Research, Heidelberg, GermanyOther articles by this author:

关键词: oridonin;    ponicidin;    irradiation;    pancreatic cancer;    γH2AX;    radiosensitivity;   

DOI  :  10.1515/raon-2017-0048

学科分类：肿瘤学

来源: Onkoloski Institut Ljubljana / Institute of Oncology Ljubljana

【 摘 要 】

BackgroundChemoradiation of locally advanced non-metastatic pancreatic cancer can lead to secondary operability by tumor mass reduction. Here, we analyzed radiomodulating effects of oridonin and ponicidin in pancreatic cancer in vitro. Both agents are ent-kaurane diterpenoids, extracted from Isodon rubescens, a plant that is well known in Traditional Chinese Medicine. Cytotoxic effects have recently been shown in different tumor entities for both agents.

【 授权许可】

Unknown