Comparison of Muscle Density in Middle-Aged and Older Chinese Adults Between a High-Altitude Area (Kunming) and a Low-Altitude Area (Beijing)

Frontiers in Endocrinology

Ling Wang¹  Xiaoguang Cheng¹  Meng Gao²  Gang Wang²  Xingli Liu²  Jingsong Yang²  Wei Song²  Liang Lyu²  Jin Yang⁵  Kai Tang⁵ 

[1] Department of Radiology, Beijing Jishuitan Hospital, Beijing, China;Department of Radiology, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China;Department of Radiology, The First People’s Hospital of Yunnan Province, Kunming, China;Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China;Medical School, Kunming University of Science and Technology, Kunming, China;

关键词: altitude;    muscle density;    muscle area;    older adults;    computed tomography;   

DOI  :  10.3389/fendo.2021.811770

来源: DOAJ

【 摘 要 】

Background and PurposeA high-altitude environment was known to have a negative effect on bone and lead to a higher incidence of hip fracture. However, the dependence of muscle composition on altitude is unclear. Thus, we aimed to compare muscle density and area in plateau and low altitude area and to determine the effect of the altitude on these outcomes.MethodsCommunity dwelling adults over 60 years old living in Beijing (elevation 50 m; 300 subjects,107 men and 193 women) or Kunming (elevation 2000 m; 218 subjects,83 men and 135 women) for more than 10 years were enrolled. Quantitative CT was performed in all subjects and cross-sectional area and attenuation measured in Hounsfield units (HU) were determined for the trunk, gluteus, and mid-thigh muscles.ResultsCompared to Beijing, Kunming adults were slimmer (Beijing men vs Kunming men: 25.08 ± 2.62 vs 23.94 ± 3.10kg/m2, P=0.013; Beijing women vs Kunming women: 25.31 ± 3.1 vs 23.98 ± 3.54 kg/m2, P= 0.001) and had higher muscle density in the L2-trunk and gluteus maximus muscles after adjustment for age and BMI (L2-trunk muscles: Beijing men 29.99 ± 4.17 HU vs Kunming men 37.35 ± 4.25 HU, P< 0.0001; Beijing women 27.37 ± 3.76 HU vs Kunming women 31.51 ± 5.12 HU, P< 0.0001; Gluteus maximus muscle: Beijing men 35.11 ± 6.54 HU vs Kunming men 39.36 ± 4.39 HU, P= 0.0009; Beijing women 31.47 ± 6.26 HU vs Kunming women 34.20 ± 5.87 HU P=0.0375). Age was similar in both cohorts and no differences were observed in the gluteus medius and minimus muscle or the mid-thigh muscle, either in the area or density.ConclusionsCompared with Beijing, the adults in Kunming had higher muscle density of the gluteus maximus and L2 trunk muscles, showing that living at a higher altitude might be beneficial to muscle quality.

【 授权许可】

Unknown