A Comparison of Co-methylation Relationships Between Rheumatoid Arthritis and Parkinson's Disease

Frontiers in Neuroscience

Hongzhi Pan¹  Yongshuai Jiang²  Simeng Hu²  Liangde Xu²  Fanwu Kong³  Rennan Feng⁴  Guoping Tang⁵ 

[1] Collaborate Research Center, Shanghai University of Medicine and Health Sciences, Shanghai, China;College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China;Department of Nephrology, The Second Affiliated Hospital, Harbin Medical University, Harbin, China;Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China;The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Jinhua, China;

关键词: Parkinson's disease (PD);    rheumatoid arthritis;    DNA methylation;    Pearson's correlation coefficients;    disease;   

DOI  :  10.3389/fnins.2018.01001

来源: DOAJ

【 摘 要 】

Rheumatoid arthritis (RA) is a complex autoimmune disease. Recent studies have identified the DNA methylation loci associated with RA and found that DNA methylation was a potential mediator of genetic risk. Parkinson's disease (PD) is a common neurodegenerative disease. Several studies have indicated that DNA methylation levels are linked to PD, and genes related to the immune system are significantly enriched in PD-related methylation modules. Although recent studies have provided profound insights into the DNA methylation of both RA and PD, no shared co-methylation relationships have been identified to date. Therefore, we sought to identify shared co-methylation relationships linked to RA and PD. Here, we calculated the Pearson's correlation coefficient (PCC) of 225,239,700 gene pairs and determined the differences and similarities between the two diseases. The global co-methylation change between in PD cases and controls was larger than that between RA cases and controls. We found 337 gene pairs with large changes that were shared between RA and PD. This co-methylation relationship study represents a new area of study for both RA and PD and provides new ideas for further study of the shared biological mechanisms of RA and PD.

【 授权许可】

Unknown