Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways

International Journal of Molecular Sciences

Bryant C. Nelson¹  Shareen H. Doak²  Erdem Coskun²  Pawel Jaruga²  Leona D. Scanlan³  Neenu Singh⁴ 

[1] Life Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK;Material Measurement Laboratory, Biomolecular Measurement Division, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899, USA;Material Measurement Laboratory, Biosystems and Biomaterials Division, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899, USA;;School of Allied Health Sciences, Faculty of Health &

关键词: engineered nanomaterials;    DNA damage;    nanotoxicity;    DNA repair proteins/genes;    DNA repair pathways;   

DOI  :  10.3390/ijms18071515

来源: DOAJ

【 摘 要 】

Some engineered nanomaterials (ENMs) may have the potential to cause damage to the genetic material in living systems. The mechanistic machinery functioning at the cellular/molecular level, in the form of DNA repair processes, has evolved to help circumvent DNA damage caused by exposure to a variety of foreign substances. Recent studies have contributed to our understanding of the various DNA damage repair pathways involved in the processing of DNA damage. However, the vast array of ENMs may present a relatively new challenge to the integrity of the human genome; therefore, the potential hazard posed by some ENMs necessitates the evaluation and understanding of ENM-induced DNA damage repair pathways. This review focuses on recent studies highlighting the differential regulation of DNA repair pathways, in response to a variety of ENMs, and discusses the various factors that dictate aberrant repair processes, including intracellular signalling, spatial interactions and ENM-specific responses.

【 授权许可】

Unknown