Fluorine-18-Labeled Fluorescent Dyes for Dual-Mode Molecular Imaging

Molecules

Gilles Ulrich¹  BenjaminH. Rotstein²  Maxime Munch² 

[1] Institut de Chimie et Procédés pour l’Énergie, l’Environnement et la Santé (ICPEES), UMR CNRS 7515, École Européenne de Chimie, Polymères et Matériaux (ECPM), 25 rue Becquerel, CEDEX 02, 67087 Strasbourg, France;University of Ottawa Heart Institute, Ottawa, ON K1Y 4W7, Canada;

关键词: positron emission tomography;    fluorine-18;    fluorescence;    molecular imaging;    dual-mode imaging;    radiofluorination;   

DOI  :  10.3390/molecules25246042

来源: DOAJ

【 摘 要 】

Recent progress realized in the development of optical imaging (OPI) probes and devices has made this technique more and more affordable for imaging studies and fluorescence-guided surgery procedures. However, this imaging modality still suffers from a low depth of penetration, thus limiting its use to shallow tissues or endoscopy-based procedures. In contrast, positron emission tomography (PET) presents a high depth of penetration and the resulting signal is less attenuated, allowing for imaging in-depth tissues. Thus, association of these imaging techniques has the potential to push back the limits of each single modality. Recently, several research groups have been involved in the development of radiolabeled fluorophores with the aim of affording dual-mode PET/OPI probes used in preclinical imaging studies of diverse pathological conditions such as cancer, Alzheimer’s disease, or cardiovascular diseases. Among all the available PET-active radionuclides, ¹⁸F stands out as the most widely used for clinical imaging thanks to its advantageous characteristics (t_1/2 = 109.77 min; 97% β⁺ emitter). This review focuses on the recent efforts in the synthesis and radiofluorination of fluorescent scaffolds such as 4,4-difluoro-4-bora-diazaindacenes (BODIPYs), cyanines, and xanthene derivatives and their use in preclinical imaging studies using both PET and OPI technologies.

【 授权许可】

Unknown