The Effect of Atorvastatin on Oxidative Stress and Renal Function in Experimental Model of Diabetic Nephropathy

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum

Mohammad TaghiMohammadi¹  NastaranFaghihi²  AkramEidi² 

[1] Baqiyatallah University of Medical Sciences;Science & Research Branch, Islamic Azad University;

关键词: diabetic nephropathy;    atorvastatin;    hyperglycemia;    oxidative stress.;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background and Objectives: Atorvastatin has multiple effects independent of lipid lowering, such as anti-inflammatory and antioxidant. The present study was performed with the purpose of determining the effect of atorvastatin on renal function and oxidative stress response in experimental model of diabetic nephropathy.   Methods: In an experimental study, male Wistar rats were randomly divided into four groups (N=24): normal, normal treatment, diabetic, diabetic treatment. The rats were made diabetic by an intravenous injection of streptozotocin (40mg/kg) and the treated rats received atorvastatin for 8 weeks (at dose of 40mg/kg/day). At the end of the experiment, blood samples were collected to measure glucose and creatinine levels. The concentration of malondialdehyde (MDA) and the activity of renal catalase were assessed.   Results: Chronic uncontrolled hyperglycemia (blood glucose>500mg/dl) significantly increased the blood creatinine in diabetic group (1.70±0.30mg/dl) compared to normal animals (0.40±0.07mg/dl), (p<0.05). Also, hyperglycemia caused a decrease in the activity of catalase enzyme (57%) along with an increase in the MDA concentration (0.15±0.02nmol/mg protein) compared to normal group (0.04±0.02nmol/mg protein). Atorvastatin significantly decreased the blood creatinine of diabetic animals (0.70±0.20mg/dl) compared to normal group (p<0.05). Finally, in the treated diabetic animals, renal activity of catalase enzyme increased (52%) and MDA concentration decreased (0.03±0.01nmol/mg protein).   Conclusion: The findings of this study indicated that atorvastatin is able to strengthen the renal antioxidant system during diabetic nephropathy. Therefore, it appears that atorvastatin prevents hyperglycemia-induced nephropathy through the inhibition of free radical production.

【 授权许可】

Unknown