Bioactivity of Enteromorpha intestinalis Polysaccharide Algae Against Hypercholestrolemic Diabetic Rats.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Magda M. Moustafa¹  Maha Z. Rizk¹  DinaM. Seoudi²  Sanaa A. Ali¹  Azza Abdel Megeed Mattloub³  Amina M. Medhat.² 

[1] Therapeutic Chemistry Department, National Research Centre;Department of Biochemistry, Faculty of Science, Ain Shams University.;Pharmacology Department, National Research Centre.

关键词: Enteromorpha intestinalis;    hyperglycemia;    hypercholesterolemia;    diabetes;    oxidative stress.;   

DOI  :  10.33887/rjpbcs/2019.10.4.13

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

The aim of this study was to evaluate the bioactivity of the polysaccharide obtained from aqueousextract of Enteromorpha intestinalis algae on hyperlipidemia, hypercholesterolemia and hyperglycemic ratsfedwith high fat and high cholesterol diets. Type 2 diabetes was induced by introduction of high fat diet as well asdaily oral injections of cholesterol for twelve consecutive weeks, followed by induction of insulin insufficiencyachieved by injection of low dose of streptozotocin. Lipid profile, diabetic and inflammatory markers, liver,kidney and heart functions besides oxidative stress were determined before and after treatment with the algalpolysaccharide and compared with reference drugs (glibenclamide along with fenofibrate). These biochemicalstudies were supported by the histopathological investigation of liver, kidney, pancreas and heart tissues. Theobtained results showed that oxidative stress and inflammatory markers associated with hypercholesterolemiaand hyperglycemia were significantly increased in rats fed high fat diet. The histopathological examinationshowed alteration in structure of liver, kidney, pancreas and heart tissues. Treatment with the polysaccharideextract or with reference drugs improved both biochemical and histological alterations. In conclusion thepresent study confers the potential effect of the extract to improve lipid profile, reduce hyperglycemia andenhance insulin secretion. Its antioxidant activity may protect against cardiovascular diseases, as well asimprovement in liver and kidney disorders.

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