Biologics for severe, chronic plaque psoriasis: An Australian cost-utility analysisCapsule Summary

JAAD International

Harish Suresh, BAct(Co-op)¹  Elena Keller, MHEcon²  Deshan F. Sebaratnam, FACD³  Helen Y. Sun, BSc(Med)Hons⁴ 

[1] Correspondence to: Helen Y. Sun, BSc(Med)Hons, Faculty of Medicine and Health, The University of New South Wales, High Street, Kensington, NSW 2052, Australia.;Department of Dermatology, Liverpool Hospital, Liverpool, New South Wales, Australia;Centre for Big Data Research in Health, The University of New South Wales, Kensington, New South Wales, Australia;Faculty of Medicine and Health, The University of New South Wales, Kensington, New South Wales, Australia;

关键词: adalimumab;    Australia;    biologic therapy;    cost-effectiveness analysis;    cost-utility analysis;    cost-benefit analysis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Biologics are a good therapeutic option for severe, chronic plaque psoriasis; however, they come with significant cost to the health care system. Objective: To conduct a cost-utility analysis of outpatient biologics (adalimumab, etanercept, guselkumab, ixekizumab, risankizumab, secukinumab, tildrakizumab, and ustekinumab) available to adults with severe, chronic plaque psoriasis from the perspective of the Australian health care system. Methods: A Markov cohort model was constructed to estimate the quality-adjusted life years (QALYs) and costs accrued for treatment pathways commencing with different first-line biologics, over a 96-week time horizon. The model adhered to the Australian Pharmaceutical Benefits Scheme eligibility criteria and guidelines. Results: A biologic treatment pathway commencing on tildrakizumab was the most cost-effective first-line treatment (Australian dollar 39,930; total utility of 1.57 QALYs over 96 weeks). First-line secukinumab and risankizumab had incremental cost-utility ratios of Australian dollar 194,524/QALY and Australian dollar 479,834/QALY, respectively, when compared with first-line tildrakizumab. Limitations: The efficacy and utility input parameters were derived from international randomized control trials and patients from the United Kingdom, respectively. Findings from this study cannot be generalized beyond Australia. Conclusion: Tildrakizumab may be considered as first-line treatment for adult patients with severe, chronic plaque psoriasis embarking on biologic therapy, from the economic perspective of the Australian health care system.

【 授权许可】

Unknown