Effect of Fructooligosaccharides Fraction fromPsacalium decompositum on Inflammation andDyslipidemia in Rats with Fructose-Induced Obesity

Nutrients

Gerardo Blancas-Flores¹  Francisco Javier Alarcón-Aguilar¹  Rubén Román-Ramos¹  Julio Cesar Almanza-Pérez¹  Gil Magos-Guerrero²  Daniel Arrieta-Baez³  Manuel Jiménez-Estrada⁴  René Javier Hernández-Bautista⁵  Ana del Carmen Susunaga-Notario⁵  Héctor Merino-Aguilar⁶ 

[1] Departamento de Ciencias de la Salud, D.C.B.S., Universidad Autónoma Metropolitana-Iztapalapa,Apdo-Postal 55-535, México D.F. C.P. 09340, Mexico;Facultad de Medicina, Universidad Nacional Autónoma de México, Coyoacán,México D.F. C.P. 04510, Mexico;Instituto Politécnico Nacional-CNMN, Calle Luis Enrique Erro s/n, Unidad Profesional Adolfo López Mateos, Col. Zacatenco, México D.F. C.P. 07738, Mexico;Instituto de Química, Universidad Nacional Autónoma de México, Coyoacán,México D.F. C.P. 04510, Mexico;Programa de Doctorado en Biología Experimental, D.C.B.S., Universidad Autónoma Metropolitana-Iztapalapa, Apdo-Postal 55-535, México D.F. C.P. 09340, Mexico;Programa de Doctorado en Ciencias Biológicas y de la Salud. D.C.B.S., Universidad Autónoma Metropolitana-Iztapalapa, Apdo-Postal 55-535, México D.F. C.P. 09340, Mexico;

关键词: Psacalium decompositum;    asteraceae;    fructose;    obesity;    dyslipidemia;    inflammatory cytokines;   

DOI  :  10.3390/nu6020591

来源: DOAJ

【 摘 要 】

Psacalium decompositum, commonly known as “Matarique,” is a medicinal plant used in Mexico for diabetes mellitus empirical therapy. Previous studies have shown that the fructooligosaccharides (FOS) present in the roots of this plant exhibit a notable hypoglycemic effect in animal models; this effect might be associated with the attenuation of the inflammatory process and other metabolic disorders. In this study, we examined the effects of FOS fraction administration in a fructose-fed rat model for obesity. Phytochemical chromatographic studies (high performance thin layer chromatography and nuclear magnetic resonance) were performed to verify isolation of FOS. 24 male Wistar rats were maintained for 12 weeks on a diet of 20% HFCS in drinking water and chow. Glucose, cholesterol, triglycerides and liver transaminases levels were measured monthly, after administering FOS fraction intragastrically (150 mg/kg/day for 12 weeks), while the levels of inflammatory cytokines were only quantified at the end of the treatments. Rats treated with FOS fraction decreased body weight, cholesterol, triglycerides, and significantly reduced IL-6, IFN-γ, MCP-1, IL-1β and VEGF levels (p < 0.05). These results suggest that P. decompositum has anti-inflammatory and hypolipidemic properties that might be used as an alternative treatment for the control of obesity.

【 授权许可】

Unknown