Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface

International Journal of Molecular Sciences

Iván P. Uray¹  Karen Uray² 

[1] Department of Clinical Oncology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary;Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary;

关键词: mechanotransduction;    plasma membrane;    cytoskeleton;    cancer;    gastrointestinal;   

DOI  :  10.3390/ijms222111566

来源: DOAJ

【 摘 要 】

Mechanical cues are crucial for survival, adaptation, and normal homeostasis in virtually every cell type. The transduction of mechanical messages into intracellular biochemical messages is termed mechanotransduction. While significant advances in biochemical signaling have been made in the last few decades, the role of mechanotransduction in physiological and pathological processes has been largely overlooked until recently. In this review, the role of interactions between the cytoskeleton and cell-cell/cell-matrix adhesions in transducing mechanical signals is discussed. In addition, mechanosensors that reside in the cell membrane and the transduction of mechanical signals to the nucleus are discussed. Finally, we describe two examples in which mechanotransduction plays a significant role in normal physiology and disease development. The first example is the role of mechanotransduction in the proliferation and metastasis of cancerous cells. In this system, the role of mechanotransduction in cellular processes, including proliferation, differentiation, and motility, is described. In the second example, the role of mechanotransduction in a mechanically active organ, the gastrointestinal tract, is described. In the gut, mechanotransduction contributes to normal physiology and the development of motility disorders.

【 授权许可】

Unknown