Membrane contact sites and cytoskeleton-membrane interactions in autophagy

FEBS Letters

article

Patrick J. Duckney¹  Pengwei Wang²  Patrick J. Hussey¹ 

[1]Department of Biosciences, Durham University

[2]Key Laboratory of Horticultural Plant Biology, College of Horticulture and Forestry Sciences, Huazhong Agricultural University

关键词: actin;    autophagy;    chloroplast;    contact site;    cytoskeleton;    endoplasmic reticulum;    membrane;    mitochondria;    plasma membrane;    vacuole;   

DOI  :  10.1002/1873-3468.14414

来源: John Wiley & Sons Ltd.

【 摘 要 】

In Eukaryotes, organelle interactions occur at specialised contact sites between organelle membranes. Contact sites are regulated by specialised tethering proteins, which bring organelle membranes into close proximity, and facilitate functional crosstalk between compartments. While contact site proteins are well characterised in mammals and yeast, the regulators of plant contact site formation are only now beginning to emerge. Having unique subcellular structures, plants must also utilise unique mechanisms of organelle interaction to regulate plant-specific functions. The recently characterised NETWORKED proteins are the first dedicated family of plant-specific contact site proteins. Research into the NET proteins and their interacting partners continues to uncover plant-specific mechanisms of organelle interaction and the importance of these organelle contacts to plant life. Moreover, it is becoming increasingly apparent that organelle interactions are fundamental to autophagy in plants. Here, we will present recent developments in our understanding of the mechanisms of plant organelle interactions, their functions, and emerging roles in autophagy.

【 授权许可】

Unknown