Case Series of COVID-19 Asymptomatic Newborns With Possible Intrapartum Transmission of SARS-CoV-2

Frontiers in Pediatrics

Olivier Morel¹  Apolline Wittwer²  Jean-Michel Hascoët²  Jean-Marc Jellimann²  Patricia Franck³  Hélène Jeulin⁴  Cedric Hartard⁴ 

[1] Department of Gynecology and Obstetrics, Maternite Regionale CHRU Nancy, Nancy, France;Division of Neonatology, Maternite Regionale, CHRU Nancy, EA 3450 Lorraine University, Nancy, France;Laboratory of Biology, CHRU Nancy, Nancy, France;Lorraine University, CNRS, LCPME, Nancy, France;Virology Unit, Department of Microbiology, Nancy, France;

关键词: newborn;    COVID-19;    vertical transmission;    antibodies;    case report;    pregnancy;   

DOI  :  10.3389/fped.2020.568979

来源: DOAJ

【 摘 要 】

Background: Despite the pandemic, data are limited regarding COVID-19 infection in pregnant women and newborns. This report aimed to bring new information about presentation that could modify precautionary measures for infants born of mothers with a remote history of COVID-19.Methods: We report two infants with possible maternofetal transmission, and four mothers without immunologic reactions. Data were collected from the patient files.Results: One mother exhibited infection signs 10 days before uncomplicated delivery, with negative RT-PCR and no antibody detection thereafter. Another mother exhibited infection 6 weeks pre-delivery, confirmed by nasopharyngeal swab testing with positive RT-PCR, and positive antibody detection (IgM and IgG). Both newborns were asymptomatic but tested positive for nasopharyngeal and stool RT-PCR at 1 and 3 days of age for the first one and at 1 day of age for stool analysis for the second one. Two additional mothers exhibited infection confirmed by positive RT-PCR testing at 28- and 31-days pre-delivery but did not present detectable antibody reaction at the time of delivery.Conclusion: These observations raise concerns regarding contamination risk by asymptomatic newborns and the efficacy of immunologic reactions in pregnant mothers, questioning the reliability of antibody testing during pregnancy.

【 授权许可】

Unknown