Synthesizing the First Phase of Dynamic Sequences of Breast MRI for Enhanced Lesion Identification

Frontiers in Oncology

Jun Yu¹  Pingping Wang¹  Jialiang Ren²  Pin Nie³  Lifang Wang³  Baoying Chen³  Rumei Liu³  Jiawei Wang³  Kaiguo Zhu³  Yanli Dang³  Hongyu Wang⁴  Jun Feng⁵  Haiming Fan⁶ 

[1] Clinical Experimental Centre, Xi’an International Medical Center Hospital, Xi’an, China;GE Healthcare China, Beijing, China;Imaging Diagnosis and Treatment Center, Xi’an International Medical Center Hospital, Xi’an, China;The School of Computer Science and Technology, Xi’an University of Posts and Telecommunications, Xi’an, China;The School of Information of Science and Technology, Northwest University, Xi’an, China;The School of Medicine, Northwest University, Xi’an, China;

关键词: generative adversarial network (GAN);    images synthesis;    breast cancer;    deep learning;    magnetic resonance imaging (MRI);   

DOI  :  10.3389/fonc.2021.792516

来源: DOAJ

【 摘 要 】

ObjectiveTo develop a deep learning model for synthesizing the first phases of dynamic (FP-Dyn) sequences to supplement the lack of information in unenhanced breast MRI examinations.MethodsIn total, 97 patients with breast MRI images were collected as the training set (n = 45), the validation set (n = 31), and the test set (n = 21), respectively. An enhance border lifelike synthesize (EDLS) model was developed in the training set and used to synthesize the FP-Dyn images from the T1WI images in the validation set. The peak signal-to-noise ratio (PSNR), structural similarity (SSIM), mean square error (MSE) and mean absolute error (MAE) of the synthesized images were measured. Moreover, three radiologists subjectively assessed image quality, respectively. The diagnostic value of the synthesized FP-Dyn sequences was further evaluated in the test set.ResultsThe image synthesis performance in the EDLS model was superior to that in conventional models from the results of PSNR, SSIM, MSE, and MAE. Subjective results displayed a remarkable visual consistency between the synthesized and original FP-Dyn images. Moreover, by using a combination of synthesized FP-Dyn sequence and an unenhanced protocol, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of MRI were 100%, 72.73%, 76.92%, and 100%, respectively, which had a similar diagnostic value to full MRI protocols.ConclusionsThe EDLS model could synthesize the realistic FP-Dyn sequence to supplement the lack of enhanced images. Compared with full MRI examinations, it thus provides a new approach for reducing examination time and cost, and avoids the use of contrast agents without influencing diagnostic accuracy.

【 授权许可】

Unknown