Association between Temporomandibular Joint Disorder and Parkinson’s Disease

Brain Sciences

Joo-Heung Yoon¹  Suk-Yun Kang²  Yeso Choi³  Tae-Hwan Chung⁴  Jee-Hye Wee⁵  Chanyang Min⁵  Dae-Myoung Yoo⁵  Hyo-Geun Choi⁵  Soo-Hwan Byun⁶  Seok-Jin Hong⁶ 

[1] Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA;Department of Neurology, College of Medicine, Hallym University, Dongtan 18450, Korea;Department of Otorhinolaryngology–Head and Neck Surgery, College of Medicine, Hallym University, Dongtan 18450, Korea;Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD 21218, USA;Hallym Data Science Laboratory, College of Medicine, Hallym University, Anyang 14068, Korea;Research Center of Clinical Dentistry, Clinical Dentistry Graduate School, Hallym University, Chuncheon 24252, Korea;

关键词: temporomandibular joint disorder;    Parkinson’s disease;    jaw movement;   

DOI  :  10.3390/brainsci11060747

来源: DOAJ

【 摘 要 】

This study performed two different analyses using a large set of population data from the Korean National Health Insurance Service Health Screening Cohort to evaluate the interactional association between temporomandibular disorder (TMD) and Parkinson’s disease (PD). Two nested case–control population-based studies were conducted on 514,866 participants. In Study I, 4455 participants with TMD were matched with 17,820 control participants, with a ratio of 1:4. In Study II, 6076 participants with PD were matched with 24,304 control participants, with a ratio of 1:4. Obesity, smoking, alcohol consumption, systolic, diastolic blood pressure, fasting blood glucose level, and total cholesterol were adjusted. The adjusted odds ratio (OR) for TMD was 1.43 (95% confidence interval (CI) = 1.02–2.00) in PD patients compared to non-PD patients in Study I (p < 0.001). The adjusted OR for PD was 1.56 (95% CI = 1.13–2.15) in TMD patients compared to non-TMD patients in Study II (p = 0.007). This study demonstrated that patients with TMD have a significantly higher risk of developing PD and, conversely, those with PD have a significantly higher risk of developing TMD.

【 授权许可】

Unknown