Assessment of safety and efficacy of perinatal or peripubertal exposure to daidzein on bone development in rats

Toxicology Reports

Yuko Tousen¹  Yoshiko Ishimi¹  Hajimu Ishiwata²  Ken Takeda³ 

[1] Department of Food Function and Labeling, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan;Department of Human Nutrition, Seitoku University, 550 Iwase, Mastudo, Chiba 271-8555, Japan;The Center for Environmental Health Science for the Next Generation, Research Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan;

关键词: Daidzein;    Bone mineral density;    Safety;    Perinatal period;    Timing of exposure;   

DOI  :  10.1016/j.toxrep.2014.12.012

来源: DOAJ

【 摘 要 】

Neonatal exposure to isoflavones improved bone health in thereafter in previous animal studies. However, since isoflavones possess hormonal activity, it may interfere with reproductive development. In the present study, we assessed the safety and efficiency of perinatal or peripubertal exposure to daidzein on bone and reproductive organ development at early adulthood in rats. Sprague-Dawley pregnant rats (n = 18) were divided into 3 groups: (1) dams and their offspring were fed the control diet. (2) Dams were fed the daidzein diet (0.5 g daidzein/kg diet) during pregnancy and then the control diet at postnatal day 13 and their offspring were fed the control diet. (3) Dams and their offspring were fed the daidzein diet through the experiment. While perinatal exposure to daidzein did not confer a positive effect on bone mineral density on postnatal day 35, peripubertal exposure to daidzein protected against a decline in bone mineral density. Meanwhile, exposure to daidzein during the perinatal or peripubertal period did not affect reproductive organ weights at early adulthood in rats. Further investigations should assess the mechanisms underlying these responses of bone metabolism to daidzein, as well as the safety of daidzein exposure during the perinatal period and throughout life.

【 授权许可】

Unknown