The Immune Microenvironment in Pancreatic Cancer

International Journal of Molecular Sciences

ThomasM. Gress¹  Christian Bauer¹  Matthias Lauth¹  Malte Buchholz¹  JörgW. Bartsch²  EmilyP. Slater³  Magdalena Huber⁴  Bilal Alashkar Alhamwe⁵  Elke Pogge von Strandmann⁵  CorinnaU. Brehm⁶ 

[1] Department of Gastroenterology, Endocrinology, Metabolism and Infectiology, Center for Tumor- and Immunology (ZTI), Philipps University Marburg, 35043 Marburg, Germany;Department of Neurosurgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany;Department of Visceral-, Thoracic- and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany;Institute for Medical Microbiology and Hospital Hygiene, Philipps University Marburg, 35043 Marburg, Germany;Institute for Tumor Immunology, Clinic for Hematology, Oncology and Immunology, Center for Tumor Biology and Immunology (ZTI), Philipps University Marburg, 35043 Marburg, Germany;Institute of Pathology, University Hospital Giessen-Marburg, 35043 Marburg, Germany;

关键词: pancreatic cancer;    tumor stroma;    T-cells;    natural killer cells;    macrophages;    neutrophils;   

DOI  :  10.3390/ijms21197307

来源: DOAJ

【 摘 要 】

The biology of solid tumors is strongly determined by the interactions of cancer cells with their surrounding microenvironment. In this regard, pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) represents a paradigmatic example for the multitude of possible tumor–stroma interactions. PDAC has proven particularly refractory to novel immunotherapies, which is a fact that is mediated by a unique assemblage of various immune cells creating a strongly immunosuppressive environment in which this cancer type thrives. In this review, we outline currently available knowledge on the cross-talk between tumor cells and the cellular immune microenvironment, highlighting the physiological and pathological cellular interactions, as well as the resulting therapeutic approaches derived thereof. Hopefully a better understanding of the complex tumor–stroma interactions will one day lead to a significant advancement in patient care.

【 授权许可】

Unknown