Quantitative and Sensitive Detection of Chloramphenicol by Surface-Enhanced Raman Scattering

Sensors

Zhenglong Wu¹  Luo Liu²  Qingyun Meng²  Hongjun Yin²  Xin Zhang²  Yufeng Ding²  Haijun Xu²  Yongmei Zhao³ 

[1] Analytical and Testing Center, Beijing Normal University, Beijing 100875, China;Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, China;Engineering Research Center for Semiconductor Integrated Technology, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China;

关键词: surface-enhanced Raman scattering;    Au nanoparticles;    chloramphenicol;    quantitative detection;   

DOI  :  10.3390/s17122962

来源: DOAJ

【 摘 要 】

We used surface-enhanced Raman scattering (SERS) for the quantitative and sensitive detection of chloramphenicol (CAP). Using 30 nm colloidal Au nanoparticles (NPs), a low detection limit for CAP of 10−8 M was obtained. The characteristic Raman peak of CAP centered at 1344 cm−1 was used for the rapid quantitative detection of CAP in three different types of CAP eye drops, and the accuracy of the measurement result was verified by high-performance liquid chromatography (HPLC). The experimental results reveal that the SERS technique based on colloidal Au NPs is accurate and sensitive, and can be used for the rapid detection of various antibiotics.

【 授权许可】

Unknown