Microwave assisted synthesis of 1H-tetrazole-based flavonoid derivatives and their antimicrobial activity

Journal of the Serbian Chemical Society

Ashok Dongamanti¹  Nagaraju Nalaparaju¹  Lakshmi Vijaya B.¹  Sarasija Madderla² 

[1] Osmania Universit, Department of Chemistry, DeparGreen and Medicinal Chemistry Laboratory, Hyderabad, Telangana, India;Satavahana University, Department of Chemistry, Karimnagar, Telangana, India;

关键词: 4-(1H-tetrazol-5-yl) benzaldehyde;    chalcone;    aurone;    microwave irradiation;    antimicrobial activity.;   

DOI  :  10.2298/JSC170825064A

来源: DOAJ

【 摘 要 】

A series of novel tetrazole scaffolds containing chalcones 4a–e and aurones 5a–e were synthesized under conventional and microwave irradiation conditions. All the newly synthesized compounds were characterized by IR, NMR and mass spectral data. Furthermore, the title compounds were screened in vitro for their antimicrobial activity against bacteria, such as Staphylococus aureus, Bacillus subtilis, Klebsiella pneumoniae and Escherichia coli, as well as fungi, such as Aspergillus niger, A. flavus and Fusarium oxysporum. Some of the compounds showed very good activity compared to standard drugs against all the tested pathogenic bacteria and fungi.

【 授权许可】

Unknown