Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview

Frontiers in Neuroscience

Andreza Fabro de Bem²  Hémelin Resende Farias³  José Cláudio Fonseca Moreira³  Rachel Krolow³  Daniel Pens Gelain³  Victória Linden de Rezende³  Jade de Oliveira³  João Miguel das Neves Duarte⁴ 

[1] Department of Experimental Medical Science, Faculty of Medicine, Lund University, Lund, Sweden;Department of Physiological Sciences, Institute of Biology, University of Brasilia, Brazilia, Brazil;Postgraduate Program in Biological Sciences: Biochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;Wallenberg Centre for Molecular Medicine, Faculty of Medicine, Lund University, Lund, Sweden;

关键词: Alzheimer’s disease;    Parkinson’s disease;    hypercholesterolemia;    obesity;    diabetes;    rodent models;   

DOI  :  10.3389/fnins.2020.604150

来源: DOAJ

【 摘 要 】

The incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the sporadic forms of Alzheimer’s and Parkinson’s disease—are increasing worldwide. Notably, obesity, diabetes, and hypercholesterolemia have been indicated as early risk factors for sporadic forms of Alzheimer’s and Parkinson’s disease. These conditions share a range of molecular and cellular features, including protein aggregation, oxidative stress, neuroinflammation, and blood-brain barrier dysfunction, all of which contribute to neuronal death and cognitive impairment. Rodent models of obesity, diabetes, and hypercholesterolemia exhibit all the hallmarks of these degenerative diseases, and represent an interesting approach to the study of the phenotypic features and pathogenic mechanisms of neurodegenerative disorders. We review the main pathological aspects of Alzheimer’s and Parkinson’s disease as summarized in rodent models of obesity, diabetes, and hypercholesterolemia.

【 授权许可】

Unknown