SARS-CoV-2 Attacks in the Brain: Focus on the Sialome

Cells

Halina Car¹  Przemyslaw Wielgat¹  Karolina Narejko¹ 

[1] Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 15A, 15-274 Bialystok, Poland;

关键词: SARS-CoV-2;    sialic acid;    COVID-19;    brain;    neurons;    inflammation;   

DOI  :  10.3390/cells11091458

来源: DOAJ

【 摘 要 】

The epidemiological observations suggest that respiratory and gastrointestinal symptoms caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) are accompanied by short- and long-term neurological manifestations. There is increasing evidence that the neuroinvasive potential of SARS-CoV-2 is closely related to its capacity to interact with cell membrane sialome. Given the wide expression of sialylated compounds of cell membranes in the brain, the interplay between cell membrane sialoglycans and the virus is crucial for its attachment and cell entry, transport, neuronal damage and brain immunity. Here, we focus on the significance of the brain sialome in the progress of coronavirus disease 2019 (COVID-19) and SARS-CoV-2-induced neuropathology.

【 授权许可】

Unknown