A Novel Synthesis of Fused Uracils: Indenopyrimidopyridazines, Pyrimidopyridazines, and Pyrazolopyrimidines for Antimicrobial and Antitumor Evalution

Molecules

Fatimah Agili¹  Samar El-Kalyoubi² 

[1] Chemistry Department, Faculty of Science (Female Section), Jazan University, Jazan 82621, Saudi Arabia;Department of Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City 11651, Cairo, Egypt;

关键词: 6-chlorouracil;    6-hydrazinyluracils;    ninhydrin;    isatin indenopyrimidopyridazines;    pyrrolopyrimidines;    pyrimidopyridazines;   

DOI  :  10.3390/molecules21121714

来源: DOAJ

【 摘 要 】

A variety of different compounds of fused uracils were prepared simply by the heating of 6-hydrazinyl-1-methyl-, 6-hydrazinyl-1-propyl-, or 6-hydrazinyl-1,3-dipropyluracil under reflux with ninhydrin, isatin, benzylidene malononitrile, benzylylidene ethyl cyanoacetate, benzil, and phenacyl bromide derivatives. The newly synthesized compounds were completely screened for antimicrobial and antitumor activity.

【 授权许可】

Unknown