Emerging and Established Histological Techniques for the Analysis of Thrombosis in COVID-19 Lungs

Frontiers in Cardiovascular Medicine

Colin E. Evans¹  Addie B. Spier² 

[1] Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States;Department of Medicine, University of Illinois College of Medicine, Rockford, IL, United States;;Department of Pediatrics, Lung and Vascular Biology Program, Stanley Manne Children's Research Institute, Ann &

关键词: thrombosis;    lung;    histology;    pulmonary;    COVID - 19;   

DOI  :  10.3389/fcvm.2021.745906

来源: DOAJ

【 摘 要 】

Coronavirus disease 2019 (COVID-19) is the potentially lethal disease that is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with COVID-19 have an increased risk of thrombosis, but the role of thrombosis in the pathogenesis and progression of severe COVID-19 remains unclear. A better understanding of the contribution of thrombosis to the development and progression of COVID-19 could lead to the development of novel COVID-19 treatments. For this reason, established and emerging histological techniques have recently been used to analyze COVID-19 lungs quantitatively and visually and in two and three dimensions. The gold standard and novel state-of the-art histological techniques that have been used to assess thrombosis in COVID-19 lungs are described in this Mini Review.

【 授权许可】

Unknown