Cyclic Peptides: Promising Scaffolds for Biopharmaceuticals

Genes

Donghyeok Gang¹  DoWook Kim¹  Hee-Sung Park¹ 

[1] Department of Chemistry, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Korea;

关键词: cyclic peptides;    biopharmaceuticals;    mRNA display;    yeast two hybrid;   

DOI  :  10.3390/genes9110557

来源: DOAJ

【 摘 要 】

To date, small molecules and macromolecules, including antibodies, have been the most pursued substances in drug screening and development efforts. Despite numerous favorable features as a drug, these molecules still have limitations and are not complementary in many regards. Recently, peptide-based chemical structures that lie between these two categories in terms of both structural and functional properties have gained increasing attention as potential alternatives. In particular, peptides in a circular form provide a promising scaffold for the development of a novel drug class owing to their adjustable and expandable ability to bind a wide range of target molecules. In this review, we discuss recent progress in methodologies for peptide cyclization and screening and use of bioactive cyclic peptides in various applications.

【 授权许可】

Unknown