Ultrasound guided electrochemotherapy for the treatment of a clear cell thymoma in a cat

Open Veterinary Journal

Alfonso Baldi¹  Enrico Pierluigi Spugnini²  Francesco Menicagli³  Michela Pettorali³ 

[1] Biopulse s.r.l., via Toledo 256, 80132 Naples, Italy and Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università della Campania “Luigi Vanvitelli”, Caserta, Italy;Biopulse s.r.l., via Toledo 256, 80132 Naples, Italy;Gianicolense Veterinary Centre, Via Lorenzo Valla 25/b, 00152 Rome, Italy;

关键词: Biphasic pulses;    Bleomycin;    Electrochemotherapy;    Feline;    Thymoma;   

DOI  :  http://dx.doi.org/10.4314/ovj.v7i1.8

来源: DOAJ

【 摘 要 】

A twelve-year-old male castrated domestic shorthair cat was presented for rapidly progressing respiratory distress. The cat was depressed, tachypneic and moderately responsive. Ultrasonography showed a mediastinal mass associated with a significant pleural effusion that needed tapping every five to seven days. Ultrasound guided biopsy yielded a diagnosis of clear cell thymoma upon histopathology. After complete staging procedures, the owner elected to treat the cat with electrochemotherapy (ECT) using systemic bleomycin. Two sessions of ultrasound guided ECT were performed at two week intervals with trains of biphasic electric pulses applied using needle electrodes until complete coverage of the area was achieved. The treatment was well tolerated and resulted in partial remission (PR). Additional sessions were performed on a monthly basis. The cat is still in PR after fourteen months. ECT resulted in improved local control and should be considered among the available adjuvant treatments in pets carrying visceral tumors.

【 授权许可】

Unknown