Macular Vessel Density Changes in Young Adults With High Myopia: A Longitudinal Study

Frontiers in Medicine

Ying Fan¹  Zhi Zheng¹  Guangyi Hu²  Haidong Zou²  Jiangnan He²  Xun Xu²  Yao Yin²  Jianfeng Zhu²  Luyao Ye²  Ya Shi²  Qiuying Chen² 

[1] Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China;Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China;

关键词: macular vessel density;    high myopia;    optical coherence tomography angiography;    retinal thickness;    longitudinal study;   

DOI  :  10.3389/fmed.2021.648644

来源: DOAJ

【 摘 要 】

Background: To characterize the longitudinal changes of macular vessel density in young adults and its associated factors.Methods: The right eyes of 309 participants (75 high myopic, 194 mild-to-moderate myopic, and 40 healthy) were followed up for 21 months. OCTA images were acquired at two visits using follow-up scans. Macular vessel density was calculated globally and in the nine early treatment diabetic retinopathy study (ETDRS) subfields of the macula superficial layer.Results: The macular vessel density significantly decreased in young myopes after a 21-month follow up (p < 0.05), with variations among sectors. Compared with healthy eyes, HM group exhibited a faster reduction in global macular vessel density (p = 0.0307) as well as in sectors of inner-inferior (II), inner-temporal (IT), and outer-temporal (OT) (all p < 0.05). Multivariate regression analysis showed that longer baseline axial length (AL) was significantly associated with larger reduction of macular vessel density in the inner-inferior, inner-temporal and outer-temporal sectors (all p < 0.05).Conclusions: Compared with emmetropes, high myopes presented greater loss of macular vessel density over time in global and in the inner-inferior, inner-temporal and outer-temporal sectors. A longer baseline AL was associated with larger changes of macular vessel density in the inner-inferior, inner-temporal and outer-temporal sectors.

【 授权许可】

Unknown