Macular Vessel Density Changes in Young Adults With High Myopia: A Longitudinal Study

Frontiers in Medicine

article

Ya Shi¹  Haidong Zou¹  Xun Xu¹  Luyao Ye¹  Qiuying Chen¹  Guangyi Hu¹  Yao Yin²  Ying Fan¹  Jianfeng Zhu²  Jiangnan He²  Zhi Zheng¹ 

[1] Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases;Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital

关键词: macular vessel density;    high myopia;    optical coherence tomography angiography;    retinal thickness;    longitudinal study;   

DOI  :  10.3389/fmed.2021.648644

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: To characterize the longitudinal changes of macular vessel density in young adults and its associated factors. Methods: The right eyes of 309 participants (75 high myopic, 194 mild-to-moderate myopic, and 40 healthy) were followed up for 21 months. OCTA images were acquired at two visits using follow-up scans. Macular vessel density was calculated globally and in the nine early treatment diabetic retinopathy study (ETDRS) subfields of the macula superficial layer. Results: The macular vessel density significantly decreased in young myopes after a 21-month follow up ( p < 0.05), with variations among sectors. Compared with healthy eyes, HM group exhibited a faster reduction in global macular vessel density ( p = 0.0307) as well as in sectors of inner-inferior (II), inner-temporal (IT), and outer-temporal (OT) (all p < 0.05). Multivariate regression analysis showed that longer baseline axial length (AL) was significantly associated with larger reduction of macular vessel density in the inner-inferior, inner-temporal and outer-temporal sectors (all p < 0.05). Conclusions: Compared with emmetropes, high myopes presented greater loss of macular vessel density over time in global and in the inner-inferior, inner-temporal and outer-temporal sectors. A longer baseline AL was associated with larger changes of macular vessel density in the inner-inferior, inner-temporal and outer-temporal sectors.

【 授权许可】

CC BY