Nonalcoholic steatohepatitis: global impact and clinical consequences

Endocrine Connections

Pegah Golabi¹  Khaled Kabarra²  Zobair M Younossi² 

[1] Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, Virginia, USA;Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, Virginia, USA;

关键词: nonalcoholic steatohepatitis;    pathophysiology;    epidemiology;    disease burden;   

DOI  :  https://doi.org/10.1530/EC-21-0048

来源: DOAJ

【 摘 要 】

Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver diseases ranging from simple fatty infiltration of liver parenchyma to the potent ially progressive type of NAFLD called nonalcoholic steatohepatitis (NASH). Given the obesity epidemic, NAFLD and NASH have reached alarming levels globally. Recent data suggest that more than a quarter of the world population is affected by NAFLD; however, t he disease prevalence is higher in certain patient population, that is, 55% prevalence rate among patients with type 2 diabetes (T2DM). Besides T2DM, NAFLD is also closely related to other metabolic abnormalities, such as visceral obesity, hypertension, and hyperlipidemia. It has been suggested that stage of liver fibrosis is the most important fac tor associated with mortality among patients with NAFLD. Additionally, patients with T2DM have increased risk of adverse outcomes. In addition to these metabolic abnormalities, older age and some genetic factors could pose additional risks. Patients with NAFLD and NASH have significantly impaired health-related quality of life than the g eneral population. There is also a growing economical impact of NAFLD and NASH on healthcare systems around the globe. Despite a number of promising regimens as treatment options, healthy lifestyle modification with diet and exercise remains at the core of manag ement of NAFLD and NASH.

【 授权许可】

Unknown