Dorsal anterior cingulate cortex in typically developing children: Laterality analysis

Developmental Cognitive Neuroscience

Chao-Gan Yan¹  Xi-Nian Zuo¹  Jue Wang¹  Ning Yang¹  Wei Liao²  Yu-Feng Zang²  Han Zhang² 

[1] Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China;Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China;

关键词: Laterality;    Anterior cingulate cortex;    Cognitive control;    Control network;    Default mode;    Development;   

DOI  :  10.1016/j.dcn.2015.10.002

来源: DOAJ

【 摘 要 】

We aimed to elucidate the dACC laterality in typically developing children and their sex/age-related differences with a sample of 84 right-handed children (6–16 years, 42 boys). We first replicated the previous finding observed in adults that gray matter density asymmetry in the dACC was region-specific: leftward (left > right) in its superior part, rightward (left < right) in its inferior part. Intrinsic connectivity analysis of these regions further revealed region-specific asymmetric connectivity profiles in dACC as well as their sex and age differences. Specifically, the superior dACC connectivity with frontoparietal network and the inferior dACC connectivity with visual network are rightward. The superior dACC connectivity with the default network (lateral temporal cortex) was more involved in the left hemisphere. In contrast, the inferior dACC connectivity with the default network (anterior medial prefrontal cortex) was more lateralized towards the right hemisphere. The superior dACC connectivity with lateral visual cortex was more distinct across two hemispheres in girls than that in boys. This connection in boys changed with age from right-prominent to left-prominent asymmetry whereas girls developed the connection from left-prominent to no asymmetry. These findings not only highlight the complexity and laterality of the dACC but also provided insights into dynamical structure–function relationships during the development.

【 授权许可】

Unknown