Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS study

Journal of Functional Foods

José Antonio García-Santos¹  Natalia Sepúlveda-Valbuena¹  Jesús Jiménez¹  Estefanía Diéguez²  Ana Nieto-Ruiz²  Roser De-Castellar³  Mercedes G. Bermúdez⁴  Cristina Campoy⁵  Florian Herrmann⁶  María García-Ricobaraza⁶  M. Teresa Miranda⁶ 

[1] EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, Spain;Instituto de Investigación Biosanitaria ibs.GRANADA, Health Sciences Technological Park, 18012 Granada, Spain;Mind, Brain and Behaviour Research Centre-CIMCYC, University of Granada, 18011 Granada, Spain;Nutrition and Biochemistry Department, Faculty of Sciences, Pontificia Universidad Javeriana, Bogotá 110231, Colombia;Department of Biostatistics, School of Medicine, University of Granada, 18016 Granada, Spain;Department of Paediatrics, School of Medicine. University of Granada. Avda. Investigación 11, 18016 Granada, Spain;

关键词: Early nutrition;    Infection;    Infant formula;    Synbiotics;    Milk fat globule membrane;   

DOI  :  

来源: DOAJ

【 摘 要 】

Functional nutrients like synbiotics or milk-fat globule membrane (MFGM) affect positively host immunity, modifying intestinal microbioma and reducing early childhood infections. We compared effects of an experimental enriched-infant formula with long chain polyunsaturated fatty acids, MFGM, synbiotics, sialic acid, nucleotides and gangliosides to a standard infant formula and breastfeeding regarding infections incidence and evolution in infants until 18 months of age. 170 healthy infants were enrolled in a RCT to receive either a bioactive functional nutrients enriched infant formula (EF, n = 85) or a standard formula (SF, n = 85). 50 breastfed (BF) infants were also enrolled. At age 12 months, EF group compared to SF and BF groups showed a lower incidence of infectious episodes. Moreover, they also presented less incidence of respiratory tract infections and gastrointestinal infections than SF infants, reducing risk by 30.2% and 32.5%, respectively. Infants fed with an EF seem to have reduced incidence of certain infections at 12 months of age.

【 授权许可】

Unknown