Stressed: The Unfolded Protein Response in T Cell Development, Activation, and Function

International Journal of Molecular Sciences

Kyeorda Kemp¹  Cody Poe² 

[1] Department of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, 586 Pioneer Drive, Rochester, MI 48309, USA;Department of Natural Sciences, Northeastern State University, 3100 New Orleans Street, Broken Arrow, OK 74014, USA;

关键词: ER stress;    UPR;    protein folding;    T cells;   

DOI  :  10.3390/ijms20071792

来源: DOAJ

【 摘 要 】

The unfolded protein response (UPR) is a highly conserved pathway that allows cells to respond to stress in the endoplasmic reticulum caused by an accumulation of misfolded and unfolded protein. This is of great importance to secretory cells because, in order for proteins to traffic from the endoplasmic reticulum (ER), they need to be folded appropriately. While a wealth of literature has implicated UPR in immune responses, less attention has been given to the role of UPR in T cell development and function. This review discusses the importance of UPR in T cell development, homeostasis, activation, and effector functions. We also speculate about how UPR may be manipulated in T cells to ameliorate pathologies.

【 授权许可】

Unknown