Integrating ER and Mitochondrial Proteostasis in the Healthy and Diseased Heart

Frontiers in Cardiovascular Medicine

article

Adrian Arrieta¹  Erik A. Blackwood¹  Winston T. Stauffer¹  Christopher C. Glembotski¹ 

[1] Department of Biology, San Diego State University Heart Institute, San Diego State University

关键词: mitochondria;    proteostasis;    UPR;    endoplasmic reticulum;    protein folding;   

DOI  :  10.3389/fcvm.2019.00193

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

The integrity of the proteome in cardiac myocytes is critical for robust heart function. Proteome integrity in all cells is managed by protein homeostasis or proteostasis, which encompasses processes that maintain the balance of protein synthesis, folding, and degradation in ways that allow cells to adapt to conditions that present a potential challenge to viability ( 1 ). While there are processes in various cellular locations in cardiac myocytes that contribute to proteostasis, those in the cytosol, mitochondria and endoplasmic reticulum (ER) have dominant roles in maintaining cardiac contractile function. Cytosolic proteostasis has been reviewed elsewhere ( 2 , 3 ); accordingly, this review focuses on proteostasis in the ER and mitochondria, and how they might influence each other and, thus, impact heart function in the settings of cardiac physiology and disease.

【 授权许可】

CC BY