期刊论文详细信息
Biomedicines | |
Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy | |
Sanjay Kumar1  BrennettaJ. Crenshaw2  Courtnee’R. Bell2  LeandraB. Jones2  QianaL. Matthews2  | |
[1] Departments of Pediatrics and Cell, Developmental and Integrative Biology, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL 35233, USA;Microbiology Program, Department of Biological Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL 36104, USA; | |
关键词: adenovirus; serotype; Mastadenovirus; epidemiology; gene therapy; exosomes; | |
DOI : 10.3390/biomedicines7030061 | |
来源: DOAJ |
【 摘 要 】
Human adenoviruses are large (150 MDa) doubled-stranded DNA viruses that cause respiratory infections. These viruses are particularly pathogenic in healthy and immune-compromised individuals, and currently, no adenovirus vaccine is available for the general public. The purpose of this review is to describe (i) the epidemiology and pathogenicity of human adenoviruses, (ii) the biological role of adenovirus vectors in gene therapy applications, and (iii) the potential role of exosomes in adenoviral infections.
【 授权许可】
Unknown