Phytochemistry of Three Ecuadorian Lamiaceae: Lepechinia heteromorpha (Briq.) Epling, Lepechinia radula (Benth.) Epling and Lepechinia paniculata (Kunth) Epling

Plants

Jorge Ramírez¹  Willan Quinche¹  Jackeline León¹  Lita Benítez¹  Vladimir Morocho¹  Nixon Cumbicus¹  Mayra Montalván¹  Gianluca Gilardoni¹  Carlo Bicchi² 

[1] Departamento de Química y Ciencias Exactas, Universidad Técnica Particular de Loja (UTPL), Calle M. Champagnat s/n, 1101608 Loja, Ecuador;Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via P. Giuria 9, 10125 Torino, Italy;

关键词: Ecuador;    Lamiaceae;    essential oil;    ledol;    caryophyllene oxide;    spathulenol;    angustanoic acid E;    5-hydroxy-4′,7-dimethoxy flavone;    guaiol;    carnosol;   

DOI  :  10.3390/plants8010001

来源: DOAJ

【 摘 要 】

In this research, the leaves of Lepechinia heteromorpha (Briq.) Epling, Lepechinia radula (Benth.) Epling and Lepechinia paniculata (Kunth) Epling have been collected in order to perform a phytochemical study. The first species was distilled to obtain a novel essential oil (EO), while the others were submitted to ethyl acetate extraction and secondary metabolite isolation. The chemical composition of the EO from L. heteromorpha has been investigated by Gas Chromatography-Mass Spectrometry (GC-MS) and Gas Chromatography with Retention Indices (GC(RI)), identifying 25 constituents. A major compound, (−)-ledol (21.2%), and a minor compound, (−)-caryophyllene oxide (1.0%), were isolated from the EO and their structures confirmed by Nuclear Magnetic Resonance (NMR) spectroscopy. Other major constituents of the EO were viridiflorene (27.3%), (E,E)-α-farnesene (1.4%), spirolepechinene and (E)-β-caryophyllene (7.1% each), allo-aromadendrene (6.1%), camphor (1.7%), limonene (1.3%) and β-phellandrene (4.6%). The enantiomeric composition of the EO monoterpene fraction was also studied, determining the enantiomeric excess and distribution of α-pinene, limonene, β-phellandrene and camphor. The ethyl acetate extract of L. radula and L. paniculata were fractionated by column chromatography. Spathulenol, angustanoic acid E and 5-hydroxy-4′,7-dimethoxy flavone were isolated from L. radula extract; ledol, guaiol and (−)-carnosol were found in L. paniculata.

【 授权许可】

Unknown