Emerging Opportunities of Radiotherapy Combined With Immunotherapy in the Era of Breast Cancer Heterogeneity

Frontiers in Oncology

Khalil Zaman¹  Laurene Cagnon²  Silvia Martin Lluesma²  Lana Kandalaft²  Pelagia G. Tsoutsou⁴  Marie-Catherine Vozenin⁵ 

[1] Department of Oncology, Breast Center, Vaudois University Hospital Centre (CHUV), Lausanne, Switzerland;Department of Oncology, Center of Experimental Therapeutics, Ludwig Center for Cancer Research, University of Lausanne, Lausanne, Switzerland;Division of Oncology, Radio-oncology Department, Vaudois University Hospital Centre (CHUV), Lausanne, Switzerland;Radiation Oncology Department, Hôpital Neuchâtelois, La Chaux-de-Fonds, Switzerland;Radio-Oncology Research Laboratory, Vaudois University Hospital Centre (CHUV), Epalinges, Switzerland;

关键词: breast cancer;    subtypes;    immunotherapy;    radiotherapy;    TILs;   

DOI  :  10.3389/fonc.2018.00609

来源: DOAJ

【 摘 要 】

The association of radiotherapy and immunotherapy has recently emerged as an exciting combination that might improve outcomes in many solid tumor settings. In the context of breast cancer, this opportunity is promising and under investigation. Given the heterogeneity of breast cancer, it might be meaningful to study the association of radiotherapy and immunotherapy distinctly among the various breast cancer subtypes. The use of biomarkers, such as tumor infiltrating lymphocytes, which are also associated to breast cancer heterogeneity, might provide an opportunity for tailored studies. This review highlights current knowledge of the association of radiotherapy and immunotherapy in the setting of breast cancer and attempts to highlight the therapeutic opportunities among breast cancer heterogeneity.

【 授权许可】

Unknown