Synthesis and in vitro antimicrobial evaluation of 5-amino-7-aryl-6-cyano-4H- pyrano[3,2,b]pyrrole derivatives catalyzed by reusable ZrOCl2•8H2O

Bulletin of the Chemical Society of Ethiopia

关键词: ZrOCl2·8H2O;    Pyranopyrrole;    Malononitrile;    3-Hydroxypyrrole;    Solvent-free;   

DOI  :  10.4314/bcse.v28i1.11

来源: DOAJ

【 摘 要 】

An efficient synthesis of a new series of 5-amino-7-aryl-6-cyano-4H-pyrano[3,2-b]pyrrole derivatives from the reaction of 3-hydroxypyrrole, malononitrile, and various aromatic aldehydes using ZrOCl2·8H2O, an environmentally friendly catalyst under a thermal solvent-free green procedure is described. This simple protocol offer advantages such as shorter reaction times, simple work-up and excellent yield. The catalyst ZrOCl2·8H2O can be reused. The reusability of the catalyst has been studied for the synthesis of 5-amino-7-aryl-6-cyano-4H-pyrano[3,2-b]pyrrole. All the compounds were screened for their antibacterial and antifungal activity. DOI:http://dx.doi.org/10.4314/bcse.v28i1.11

【 授权许可】

Unknown