The Endolysosomal System: The Acid Test for SARS-CoV-2

International Journal of Molecular Sciences

Ana LuciaMoraes Giannini¹  Cecília Jacques G. de Almeida²  Daniella Cesar-Silva²  Filipe S. Pereira-Dutra² 

[1] Laboratory of Functional Genomics and Signal Transduction, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, Brazil;Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil;

关键词: lysosome;    endosome;    acidification;    coronaviruses;    endocytosis;    autophagy;   

DOI  :  10.3390/ijms23094576

来源: DOAJ

【 摘 要 】

This review aims to describe and discuss the different functions of the endolysosomal system, from homeostasis to its vital role during viral infections. We will initially describe endolysosomal system’s main functions, presenting recent data on how its compartments are essential for host defense to explore later how SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) and other coronaviruses subvert these organelles for their benefit. It is clear that to succeed, pathogens’ evolution favored the establishment of ways to avoid, escape, or manipulate lysosomal function. The unavoidable coexistence with such an unfriendly milieu imposed on viruses the establishment of a vast array of strategies to make the most out of the invaded cell’s machinery to produce new viruses and maneuvers to escape the host’s defense system.

【 授权许可】

Unknown